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Single-gene testing combined with single nucleotide polymorphism microarray preimplantation genetic diagnosis for aneuploidy: a novel approach in optimizing.

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Presentation on theme: "Single-gene testing combined with single nucleotide polymorphism microarray preimplantation genetic diagnosis for aneuploidy: a novel approach in optimizing."— Presentation transcript:

1 Single-gene testing combined with single nucleotide polymorphism microarray preimplantation genetic diagnosis for aneuploidy: a novel approach in optimizing pregnancy outcome  Paul R. Brezina, M.D., M.B.A., Andrew Benner, M.S., Svetlana Rechitsky, Ph.D., Anver Kuliev, Ph.D., Ekaterina Pomerantseva, Ph.D., Dana Pauling, M.S., C.G.C., William G. Kearns, Ph.D.  Fertility and Sterility  Volume 95, Issue 5, Pages 1786.e e8 (April 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Microarray and single gene diagnosis for corresponding embryos. Fertility and Sterility  , 1786.e e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 A karyotypic sample reading using 23-chromosome SNP microarray from an embryo that demonstrated monosomy of chromosome 8. Freq = frequency. Fertility and Sterility  , 1786.e e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Preimplantation genetic diagnosis by blastocyst analysis for mutations R59C and R201C in GLB1 gene and linked markers. Fertility and Sterility  , 1786.e e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


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