1. Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia

2. Program Goals

3. Factor Replacement Therapy

4. Challenges of Factor Replacement Therapy

5. Half-Life Extension Technology

6. rFIX Fc Fusion Protein (rFIX-Fc)

7. rFIX-Fc (cont)

8. rFIX Albumin Fusion Protein (rFIX-FP)

9. rFIX-FP (cont)

10. GlycoPEGylated rFIX (N9-GP)

11. N9-GP (cont)

12. GlycoPEGylated rFVIII (N8-GP)

14. rFVIII Fc Fusion Protein (rFVIII-Fc)

15. rFVIII-Fc (cont)

16. rFIX-Fc: Phase 3 Studies Dosing

17. rFIX-Fc: Bleeding Rate by Dose

18. rFVIII-Fc: Bleeding Rate by Dose

19. rFVIII-Fc: Dosing Frequency at the End of the Study Period

20. Summary

21. Clinical Impact of Half-life Extension

22. Abbreviations

23. References

24. References (cont)