7. Case #1

8. Case #1 (cont)

9. Case #1 (cont)

10. Resting HR Matters

11. HR and β-Blocker Dose A Complex Issue

12. EVEREST Trial

13. Multiple HR Targets for Evaluation

14. MERIT-HF

15. Uptitration in Older Population

16. Ivabradine and If Channel

17. SHIFT Trial Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial

19. Effect of Ivabradine on Outcomes

20. SHIFT No Impact of β-Blocker Dose

21. Post hoc Analysis From the Phase 3 SHIFT Study

22. CHARM HR and Outcome in HF by Rhythm

24. Incidence of Selected Adverse Events (n = 19,083)

25. Highlighting Key Points

26. Abbreviations

27. References

28. References (cont)

29. References (cont)

30. References (cont)