1. Core Facilities at UCSF and Beyond
Teri Liegler, PhD Director
ARI-UCSF Laboratory of Clinical Virology
CFAR Virology Core Laboratory
November 18, 2016
CFAR Mentoring

2. What is a Core? A centralized shared resource Provides access to
Instruments
Technologies
Services
Cell, animal, human support
Expert consultation
Cores come in many flavors, with varied operational models
November 18, 2016
CFAR Mentoring

3. Why and when to use a Core?
Expand your research scope and capacity
Expedite progress by using services already up and running
Save money by ‘renting’ rather than ‘buying’
Gain critical insight by consulting with experts throughout the study
Especially at the inception stage
November 18, 2016
CFAR Mentoring

4. Managing Core use can be daunting!
Specimens
Nucleic Acid
Extraction and Modification
Bioinformatics
HIV Sequencing
Genomic SNP Analysis
November 18, 2016
CFAR Mentoring

5. Core Synergy at Work! = CFAR Clin and Specimen Core
CFAR Immunology Core
Manuscript
CFAR Virology Core
UCSF Genomics Core
November 18, 2016
CFAR Mentoring

6. Successful Core use through partnerships
Your role
Picking the right Core for the work needed
Project ownership
Clarifying your needs (timeline, materials, resources, budget)
Defining project scope, complexity
Core’s role
Confirming it’s the right Core. If not, referral to others
Established competency in all areas of service
Interact with other cores if needed
Defining deliverables (including timeline, defined services, budget, charge components)
Clarity on “what if’s” (early termination, sample loss)
November 18, 2016
CFAR Mentoring

7. So how do I find the right Core?
>80 Cores at UCSF, 867 research resources
Add more with affiliated institutions
November 18, 2016
CFAR Mentoring

8. December 20, 2013
CFAR Mentoring

9. What are the CFAR Scientific Cores?
Clinical/Population Science
Jeff Martin MD, MPH, Steve Deeks MD
Immunology
Jeff Milush PhD
Pharmacology
Fran Aweeka PharmD
Specimen Banking
John Greenspan BDS, PhD, Yvonne DeSouza
Virology
Teri Liegler, PhD
11/20/2015
CFAR Mentoring

10. Why are CFAR Cores special?
CFAR Cores exist to promote ‘Value Added’ services
Education, training and mentoring
State of the art equipment
New assay development
Customized services
Streamlined interaction with other CFAR cores
“Conception − to − Publication” support for projects
November 18, 2016
CFAR Mentoring

11. 121410
CFAR Mentoring

12. November 18, 2016
CFAR Mentoring

13. Blood Systems Research Institute (BSRI) Cores
Bioinformatics, Xutao Deng
Cell Therapy, Marcus Muench
Epidemiology, Roberta Bruhn & Anne Guiltinan
Immunology, Sheila Keating
Molecular Transfusion (real-time PCR), Tzong-Hae Lee Viral Reference Lab & Repository, Mars Stone Virology Core, Eric Delwart
November 18, 2016
CFAR Mentoring

14. Gladstone Cores
November 18, 2016
CFAR Mentoring

15. But can I afford using a core?
You get what you pay for!
Quality, accountability and experience
Sometimes, time is $$
May partially cover costs for new development work
Consult with core director on study design, hypothesis, sample selection and services early in process
Institutional supplements
November 18, 2016
CFAR Mentoring

16. Pilot program up to $4,000
Remove barriers for 1st time core users
Expand the scope and breadth of core users
Spark new offerings and collaborations with cores
Easy app, rapid turnaround, 6 month duration

17. Questions? tliegler@sfgh.ucsf.edu 206-8929
Thank You and Good Luck!
Questions?
November 18, 2016
CFAR Mentoring