1. Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.139
Figure 3 Use of genome editing to rapidly generate isogenic hPSCs and differentiated cells
Figure 3 | Use of genome editing to rapidly generate isogenic hPSCs and differentiated cells. Genome editing can be used to introduce a mutation in wild-type human pluripotent stem cells (hPSCs) or to correct a mutation in patient-derived induced pluripotent stem cells (iPSCs). The resulting isogenic cell lines can then be differentiated into the desired tissue type. In principle, any phenotypic differences between the differentiated cell lines can be attributed to the mutation.
Strong, A. & Musunuru, K. (2016) Genome editing in cardiovascular diseases
Nat. Rev. Cardiol. doi: /nrcardio