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Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the.

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Presentation on theme: "Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the."— Presentation transcript:

1 Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the mucosa of the small intestine in infants with cow’s milk–sensitive enteropathy  Hai Lee Chung, MDa, Jin Bok Hwang, MDa, Young Dae Kwon, MDa, Min Ho Park, MDa, Won Jeong Shin, MDa, Jae Bok Park, MDb  Journal of Allergy and Clinical Immunology  Volume 103, Issue 6, Pages (June 1999) DOI: /S (99) Copyright © 1999 Mosby, Inc. Terms and Conditions

2 Fig. 1 Extracellular deposition of MBP was mainly seen within mucosal lamina propria. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

3 Fig. 2 Extracellular deposition of MBP was significantly greater in the CMSE group compared with the non-CMSE and control groups (P < .05, respectively). Median values are represented by horizontal bars. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

4 Fig. 3 VCAM-1 expression on mononuclear cells was observed within mucosal lamina propria. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

5 Fig. 4 VCAM-1 expression on mononuclear cells in mucosal lamina propria was significantly higher in the CMSE group compared with the non-CMSE and control groups (P < .05, respectively). Mean values are represented by horizontal bars . Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

6 Fig. 5 Robust expression of ICAM-1 on vascular endothelial cells and inflammatory cells in mucosal lamina propria. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

7 Fig. 6 ICAM-1 expression increased in both CMSE and non-CMSE groups without significant intergroup difference. Mean values are represented by horizontal bars . NS, Not significant Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

8 Fig. 7 There was a statistically significant relationship between the severity of villous atrophy and the extracellular MBP deposition in the CMSE group (r = 0.79, P < .001). Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

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