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Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery  Uwe M Fischer, MD, Paschalis Tossios, MD, Astrid Huebner,

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Presentation on theme: "Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery  Uwe M Fischer, MD, Paschalis Tossios, MD, Astrid Huebner,"— Presentation transcript:

1 Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery 
Uwe M Fischer, MD, Paschalis Tossios, MD, Astrid Huebner, MD, Hans J Geissler, MD, Wilhelm Bloch, PhD, Uwe Mehlhorn, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 128, Issue 1, Pages (July 2004) DOI: /j.jtcvs

2 Figure 1 Immunostaining for active caspases-3 and -7 in cardiac myocytes and capillaries shows that compared with before CPB (a and e), LV cardiac myocytes of the placebo group demonstrated caspase-3 (b) and caspase-7 (f) activation at the end of CPB. In contrast, cardiac myocytes of the NAC group, even if slightly stained before CPB (c and g), were negative for both active caspase-3 (d) and active caspase-7 (h) at the end of CPB (bar = 35 μm). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs )

3 Figure 2 Change from before CPB to the end of CPB in cardiac myocyte density for active caspases-3 and -7 in both groups (data are mean ± SD; for caspase-3, n = 18 in the placebo group; n = 18 in the N-acetylcysteine group; for caspase-7, n = 17 in the placebo group; n = 17 in the N-acetylcysteine group). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs )


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