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Association of neonatal hypoxia with lasting changes in left ventricular gene expression: An animal model  Danny Del Duca, MD, Guoruey Wong, BASc, Phan.

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Presentation on theme: "Association of neonatal hypoxia with lasting changes in left ventricular gene expression: An animal model  Danny Del Duca, MD, Guoruey Wong, BASc, Phan."— Presentation transcript:

1 Association of neonatal hypoxia with lasting changes in left ventricular gene expression: An animal model  Danny Del Duca, MD, Guoruey Wong, BASc, Phan Trieu, BSc, Demetra Rodaros, BSc, Athanasios Kouremenos, BSc, Artavazd Tadevosyan, MSc, George Vaniotis, BSc, Louis R. Villeneuve, MSc, Christo I. Tchervenkov, MD, Stanley Nattel, MD, Bruce G. Allen, PhD, Terence E. Hébert, PhD, Charles V. Rohlicek, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 138, Issue 3, Pages e1 (September 2009) DOI: /j.jtcvs Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Volcano plots generated with significance analysis of microarrays illustrating global changes in left ventricular gene expression in 10-day-old (A) and 90-day-old (B) animals after neonatal hypoxia. Individual genes are represented as points, and log of fold change (x-axis) is plotted against negative log of P value (y-axis). Thresholds have been adjusted such that genes situated between two vertical lines have less than 1.5-fold upregulation or downregulation, and genes with P values greater than .05 are situated below horizontal line. Genes situated in either right or left upper quadrant (darker diamonds) are considered to be significantly upregulated or downregulated, respectively. C, Numeric representation of gene expression changes summarized for 10- and 90-day-old animals. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Representative confocal microscopy images of freshly isolated left ventricular cardiomyocytes from 90-day-old control animals (A) and age-matched animals exposed to neonatal hypoxia (B). C, Percentage viability of cardiomyocytes after isolation procedure. Data presented are mean ± SEM of 6 independent experiments. Asterisk indicates P = .024. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

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