1. An Uncommon Tail about the Common γ-Chain
Stephen C. Jameson, Kristin R. Renkema 
Immunity 
Volume 40, Issue 6, Pages (June 2014)
DOI: /j.immuni
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
Telling Tails
In resting T cells (left), γc is produced as a membrane bound form (mγc) that joins with cytokine-specific receptor chains to mediate cytokine binding and receptor signaling though activation of JAK kinases that are associated with the cytoplasmic tails of the receptors (indicated by circles). In activated T cells, however, alternative splicing also generates sγc, a secreted form of γc (right). sγc lacks the transmembrane and cytoplasmic tail and includes a novel C terminus (purple), which includes a cysteine that is probably involved in sγc dimer formation. sγc is thought to act as a competitive antagonist for mγc binding to cytokine-specific receptor chains, thereby blocking cytokine receptor signaling. Some γc cytokine receptors include a third receptor chain (not shown).
Immunity  , DOI: ( /j.immuni )
Copyright © 2014 Elsevier Inc. Terms and Conditions