1. Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland–derived vascular endothelial growth factor and prokineticin receptor polymorphisms 
Mei-Tsz Su, M.D., Ph.D., Sheng-Hsiang Lin, Ph.D., Yi-Chi Chen, Ph.D., Pao-Lin Kuo, M.D. 
Fertility and Sterility 
Volume 102, Issue 4, Pages e3 (October 2014)
DOI: /j.fertnstert
Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
(A) Distribution of high-risk and low-risk genotypes in the best two-locus model [PROKR1 (I379V) and PROKR2 (V331M)]. High-risk (dark shading) and low-risk (light shading) genotypes associated with recurrent miscarriages show two-locus interaction. The numbers of recurrent miscarriage (RM) subjects (left black bar in boxes) and control subjects (right black bar in boxes) are shown for each genotype combination. ∗The genotype combination that confers significant less susceptibility to RM (P<.05). (B) Distribution of high-risk and low-risk genotypes in the best three-locus model [EG-VEGF (V67I), PROKR1 (I379V), and PROKR2 (V331M)]. High-risk (dark shading) and low-risk (light shading) genotypes associated with recurrent miscarriages show three-locus interaction. The numbers of RM subjects (left black bar in boxes) and control subjects (right black bar in boxes) are shown for each genotype combination.
Fertility and Sterility  , e3DOI: ( /j.fertnstert )
Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3. Supplemental Figure 1
Endocrine gland–derived vascular endothelial growth factor (EG-VEGF) variants identified in patients with recurrent miscarriage and control subjects. Schematic representation of variants identified in the EG-VEGF gene, with only one nonsynonymous variant (V67I) among them.
Fertility and Sterility  , e3DOI: ( /j.fertnstert )
Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions