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International Journal of Cardiology

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Presentation on theme: "International Journal of Cardiology"— Presentation transcript:

1 International Journal of Cardiology
Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors  Jacek Kubica, Aldona Kubica, Bernd Jilma, Piotr Adamski, Eva-Luise Hobl, Eliano Pio Navarese, Jolanta Maria Siller-Matula, Anita Dąbrowska, Tomasz Fabiszak, Marek Koziński, Paul Alfred Gurbel  International Journal of Cardiology  Volume 215, Pages (July 2016) DOI: /j.ijcard Copyright © 2016 The Authors Terms and Conditions

2 Fig. 1 The possible route of interaction between morphine and P2Y12 receptor inhibitors. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 The Authors Terms and Conditions

3 Fig. 2 Plasma concentrations of ticagrelor and AR-C124910XX in healthy volunteers and in patients with myocardial infarction. Plasma concentrations of ticagrelor (upper panel) and AR-C124910XX (lower panel) after oral administration of a 180mg ticagrelor loading dose, with (red) or without (blue) following intravenous injection of morphine in patients with myocardial infarction and healthy volunteers. Superimposed data from two randomized studies [39,42]. Data present means±standard error of the mean. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 The Authors Terms and Conditions

4 Fig. 3 Platelet reactivity after loading dose of ticagrelor in healthy volunteers and in patients with myocardial infarction. ADP-induced platelet aggregation after oral administration of a 180mg ticagrelor loading dose, with (red) or without (blue) following intravenous injection of morphine in patients with myocardial infarction and healthy volunteers. Superimposed data from two randomized studies [39,42]. Data present means±standard error of the mean. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 The Authors Terms and Conditions


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