1. Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.175
Figure 2 Potential mechanisms of action of low-dose methotrexate in rheumatoid arthritis
Figure 2 | Potential mechanisms of action of low-dose methotrexate in rheumatoid arthritis. Several mechanisms have been proposed to explain the observed clinical effects of methotrexate in rheumatoid arthritis, including antagonism of folate-dependent processes, stimulation of adenosine signalling, inhibition of methyl-donor production, generation of reactive oxygen species, downregulation of adhesion-molecule expression, modification of cytokine profiles and downregulation of eicosanoids and matrix metalloproteinases (MMPs).
Brown, P. M. et al. (2016) Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers
Nat. Rev. Rheumatol. doi: /nrrheum