2. Interaction of hypercholesterolemia and inflammation in atherogenesis
VBWG
Hypercholesterolemia
Adherence of monocytes to arterial endothelium
Penetration of monocytes into the artery
Phenotypic modulation, expression of scavenger receptors, uptake of modified LDL
Smooth muscle cells
Fatty streak, made up mainly of cholesterol-rich foam cells
Steinberg D. Nat Med. 2002;8:

3. Pathophysiology of atherosclerotic CV disease in the metabolic syndrome
VBWG
Genetic variation
Environmental factors
Central adiposity
Innate immunity
Inflammatory markers
Cytokines
Adipokines
Monocyte/macrophage
Atherosclerosis
Adipocyte
Insulin resistance
 TG Metabolic syndrome  HDL
 BP
Plaque rupture/thrombosis
Cardiovascular events
Reilly MP, Rader DJ. Circulation. 2003;108: