Presentation is loading. Please wait.

Presentation is loading. Please wait.

Scientific Advances in Lung Cancer 2015

Published byRainer Eberhardt Modified over 6 years ago

Similar presentations

Presentation on theme: "Scientific Advances in Lung Cancer 2015"— Presentation transcript:

1 Scientific Advances in Lung Cancer 2015
Anne S. Tsao, MD, Giorgio V. Scagliotti, MD, PhD, Paul A. Bunn, MD, David P. Carbone, MD, PhD, Graham W. Warren, MD, PhD, Chunxue Bai, MD, PhD, Harry J. de Koning, MD, PhD, A. Uraujh Yousaf-Khan, MD, Annette McWilliams, M.B.B.S., FRACP, Ming Sound Tsao, MD, FRCPC, Prasad S. Adusumilli, MD, FCCP, Ramón Rami-Porta, MD, Hisao Asamura, MD, Paul E. Van Schil, MD, PhD, Gail E. Darling, MD, FRCSC, Suresh S. Ramalingam, MD, Daniel R. Gomez, MD, Kenneth E. Rosenzweig, MD, Stefan Zimmermann, MD, Solange Peters, MD, PhD, Sai-Hong Ignatius Ou, MD, PhD, Thanyanan Reungwetwattana, MD, MSc, Pasi A. Jänne, MD, PhD, Tony S. Mok, MD, Heather A. Wakelee, MD, Robert Pirker, MD, Julien Mazières, MD, PhD, Julie R. Brahmer, MD, Yang Zhou, PhD, MPH, Roy S. Herbst, MD, PhD, Vassiliki A. Papadimitrakopoulou, MD, Mary W. Redman, PhD, Murry W. Wynes, PhD, David R. Gandara, MD, Ronan J. Kelly, MD, MBA, Fred R. Hirsch, MD, PhD, Harvey I. Pass, MD  Journal of Thoracic Oncology  Volume 11, Issue 5, Pages (May 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Survival curves according to treatment arm (chemotherapy versus observation) in the acinar/papillary (A, C, and E) and micropapillary/solid (B, D, and F) subgroups for overall (A and B), disease-free (C and D), and specific disease-free survival (E and F). p Values from log-rank test, hazard ratios (HRs), and 95% confidence intervals (CIs) of treatment effect, which were estimated through a univariable Cox model stratified on trial, are reported for each subgroup and end point. Reprinted with permission from Tsao et al.51 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Frequency of molecular aberrations in various driver oncogenes in lung adenocarcinomas and current available drugs against these oncogenic proteins. These frequencies are a combination of data from the Lung Cancer Mutation Consortium and frequencies listed in Shea et al.81 Shown in the boxes are the available drugs in addition to their developmental phase. EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma receptor tyrosine kinase; MET, mesenchymal-to-epithelial transition factor; HER2, erb-b2 receptor tyrosine kinase 2; ROS1, ROS proto-oncogene 1, receptor tyrosine kinase; BRAF, B-Raf proto-oncogene, serine/threonine kinase; RET, ret proto-oncogene; NTRK1, neurotrophic tyrosine kinase receptor type 1; PIK3A, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; MEK1, mitogen-activate protein kinase kinase 1; KRAS, Kirsten rat sarcoma viral oncogene homolog. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Overall survival by clinical stage according to the seventh edition (A) and the proposed eighth edition (B) of the tumor, node, and metastasis (TNM) classification. Groupings use the entire database available for the eighth edition. Survival is weighted by type of database submission: registry versus other. Reprinted with permission from Goldstraw et al.86 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Overall survival by pathological stage according to the seventh edition (A) and the proposed eighth edition (B). Groupings use the entire database available for the eighth edition. Survival is weighted by type of database submission: registry versus other. MST, median survival time; NR, not reached. Reprinted with permission from Goldstraw et al.86 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

6 Figure 5 Schema of the ALCHEMIST study. *Adjuvant radiotherapy is allowed if indicated; patients who decline adjuvant chemotherapy are eligible. **ALK positivity defined by fluorescence in situ hybridization test. NSCLC, nonsmall cell lung cancer; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma receptor tyrosine kinase; BID, twice daily; Q 2 weeks, every 2 weeks. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

7 Figure 6 Illustration showing the role of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway in suppressing antitumor immunity. Available therapies against PD-1 and PD-L1 are shown in the boxes along with their phase of development. IFNγ, interferon gamma; MHC, major histocompatibility complex; PD-L2, programmed death ligand 2; Abs, antibodies; NFκB, nuclear factor kappa light-chain enhancer of activated B cells. Modified with permission from Sznol et al.233 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

8 Figure 7 Schema of the Lung-MAP (S1400) study. Biomarker-driven substudies will progress to phase III if the study meets its end point and a phase III is feasible, at which point the standard of care arm will be determined. TBD, to be determined; PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase positive; CCGA, cell cycle gene alteration positive; FGFR, fibroblast growth factor receptor positive. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Download ppt "Scientific Advances in Lung Cancer 2015"

Similar presentations

Advances in Molecular Biology of Lung Disease

Advances in Molecular Biology of Lung Disease
Prognostic and Predictive Value of Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation Status and Gene Copy Number for Adjuvant Chemotherapy.

Prognostic and Predictive Value of Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation Status and Gene Copy Number for Adjuvant Chemotherapy.
Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non–Small-Cell Lung Cancer?: A Pooled.

Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non–Small-Cell Lung Cancer?: A Pooled.
Epidermal Growth Factor Receptor-Related Tumor Markers and Clinical Outcomes with Erlotinib in Non-small Cell Lung Cancer: An Analysis of Patients from.

Epidermal Growth Factor Receptor-Related Tumor Markers and Clinical Outcomes with Erlotinib in Non-small Cell Lung Cancer: An Analysis of Patients from.
Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab  Tomoko Funazo,

Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab  Tomoko Funazo,
Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors  Alexa B. Schrock,

Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors  Alexa B. Schrock,
Chee Khoon Lee, PhD, Johnathan Man, M. B. B. S

Chee Khoon Lee, PhD, Johnathan Man, M. B. B. S
Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non–Small Cell Lung Cancer  Martin Reck, MD, PhD, Normand Blais,

Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non–Small Cell Lung Cancer  Martin Reck, MD, PhD, Normand Blais,
A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R 

A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R 
Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.

Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.
Scientific Advances in Thoracic Oncology 2016

Scientific Advances in Thoracic Oncology 2016
Daniel Morgensztern, MD, Meghan J. Campo, MD, Suzanne E

Daniel Morgensztern, MD, Meghan J. Campo, MD, Suzanne E
Detection and Monitoring of the BRAF Mutation in Circulating Tumor Cells and Circulating Tumor DNA in BRAF-Mutated Lung Adenocarcinoma  Nicolas Guibert,

Detection and Monitoring of the BRAF Mutation in Circulating Tumor Cells and Circulating Tumor DNA in BRAF-Mutated Lung Adenocarcinoma  Nicolas Guibert,
Cases of ALK-Rearranged Lung Cancer with 5-Year Progression-Free Survival with Crizotinib as Initial Precision Therapy  Deepa Rangachari, MD, Xiuning.

Cases of ALK-Rearranged Lung Cancer with 5-Year Progression-Free Survival with Crizotinib as Initial Precision Therapy  Deepa Rangachari, MD, Xiuning.
Latest Advances in Chemotherapeutic, Targeted, and Immune Approaches in the Treatment of Metastatic Melanoma  Darshil J. Shah, MD, MPH, Roxana S. Dronca,

Latest Advances in Chemotherapeutic, Targeted, and Immune Approaches in the Treatment of Metastatic Melanoma  Darshil J. Shah, MD, MPH, Roxana S. Dronca,
Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non–Small-Cell Lung Cancer?: A Pooled.

Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non–Small-Cell Lung Cancer?: A Pooled.
Jessica J. Lin, MD, Lauren L. Ritterhouse, MD, PhD, Siraj M

Jessica J. Lin, MD, Lauren L. Ritterhouse, MD, PhD, Siraj M
Ground glass opacities: Imaging, pathology, and gene mutations

Ground glass opacities: Imaging, pathology, and gene mutations
Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens  Judith N. Müller, PhD, Markus Falk, PhD, Jatin Talwar, MSc, Nicole.

Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens  Judith N. Müller, PhD, Markus Falk, PhD, Jatin Talwar, MSc, Nicole.
The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification.

The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification.

Similar presentations

Ads by Google