1. Quick review of `stereochemical’ ideas so far:
Chiral

2. (crossed Nicols) polarimeter
Quicky review (continued)
condition for molecules to exhibit `handedness’ ?
Tetrahedral central atom must be connected to 4 non-equivalent chemical groups
Special word used to describe to above condition?
Chiral
handedness is experimentally detected with
what device ?
(crossed Nicols) polarimeter

3. Name of quantity measured with a polarimeter:
Quicky review (continued)
Name of quantity measured with a polarimeter:
Optical rotation,  (in degrees)
If you turn the analyzing polarizer counterclockwise to find , the sign of the polarization is…..
Negative (-)
Does a right-handed sugar always produce a (+) rotation ?
No…no connection between sign and right /left-handedness
What does the `D’ stand for in the specific rotation value DT ?
Wavelength of light used is the orange-colored sodium D line at 589 nm

4. Coming out of the slide towards you
Quicky review (continued)
Name for the 2D `crossed’ representation of a chiral center like that shown here:
Fischer projection
Which way are the horizontal species above oriented relative to the plane of this slide ?
Coming out of the slide towards you
Which way are the vertical species above oriented relative to the plane of this slide ?
Moving into the slide away from you

5. Fischer’s D and L notation
Quicky review (continued)
Name the icky, hard way that Doc hates that is used to designate `handedness’ for sugars and amino acids
Fischer’s D and L notation
What is the `I haz a happee’ modern way to designate handedness (which we learn today…)
Prelog-Cahn-Ingold R and S notation
(for all chiral species)

6. Chance favors the _________________________ prepared mind
Quicky review (continued)
Chance favors the _________________________
prepared mind