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Dermatomyositis associated with generalized subcutaneous edema and Evans syndrome  Kyu Dong Jung, MD, Pyoung Su Kim, MD, Hae Young Park, MD, Cho Rok Kim,

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Presentation on theme: "Dermatomyositis associated with generalized subcutaneous edema and Evans syndrome  Kyu Dong Jung, MD, Pyoung Su Kim, MD, Hae Young Park, MD, Cho Rok Kim,"— Presentation transcript:

1 Dermatomyositis associated with generalized subcutaneous edema and Evans syndrome 
Kyu Dong Jung, MD, Pyoung Su Kim, MD, Hae Young Park, MD, Cho Rok Kim, MD, Ji Yeon Byun, MD, Dong Youn Lee, MD, PhD, Joo Heung Lee, MD, PhD, Jun-Mo Yang, MD, PhD, Eil-Soo Lee, MD, PhD  Journal of the American Academy of Dermatology  Volume 66, Issue 1, Pages (January 2012) DOI: /j.jaad Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Generalized edema in 52-year-old woman with dermatomyositis. Clinical appearance on admission. Severe generalized edema with heliotropic rash in both eyelids and Gottron papules on her hands. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Biopsy specimen of right rectus femoris muscle revealing perifascicular muscle fiber atrophy with regeneration and perivascular and interstitial lymphocytic infiltrate consistent with dermatomyositis (A). Coronal, axial magnetic resonance image of both lower extremities. Enhanced T1-weighted scan shows increased intensity of anterior thigh muscle (solid arrows) (B). Fat-suppressed T2-weighted scan shows marked edematous thickening involving subcutaneous fat layer (solid arrow) (C). Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Time course of treatment and examination. AZ, Azathioprine; BM, bone-marrow examination; CT, computed tomography; DM, dermatomyositis; EMG, electromyogram; GSE, generalized subcutaneous edema; IVIG, intravenous immunoglobulin; MPD, methylprednisolone; MRI, magnetic resonance image; PBS, peripheral blood smear; PD, prednisone; US, ultrasound. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

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