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Histologic Evolution From Adenocarcinoma to Squamous Cell Carcinoma After Gefitinib Treatment  Min-Shu Hsieh, MD, Jie-Yang Jhuang, MD, Syue-Fong Hua,

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Presentation on theme: "Histologic Evolution From Adenocarcinoma to Squamous Cell Carcinoma After Gefitinib Treatment  Min-Shu Hsieh, MD, Jie-Yang Jhuang, MD, Syue-Fong Hua,"— Presentation transcript:

1 Histologic Evolution From Adenocarcinoma to Squamous Cell Carcinoma After Gefitinib Treatment 
Min-Shu Hsieh, MD, Jie-Yang Jhuang, MD, Syue-Fong Hua, Yueh-Hung Chou, MD  The Annals of Thoracic Surgery  Volume 99, Issue 1, Pages (January 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Case 1. (A) Chest computed tomography scan showing one huge lung tumor in the right lung. (B) The first biopsy showed an adenocarcinoma (hematoxylin and eosin stain, original magnification × 200) immunoreactive to thyroid transcription factor-1 (inset, original magnification × 200). (C) After tyrosine kinase inhibitor treatment, the residual tumor comprised only squamous cell carcinoma (hematoxylin and eosin stain, original magnification × 200), which was p40(+) (inset, original magnification × 200) and (D) strongly immunoreactive to anti-epidermal growth factor receptor E746–A750 del antibodies (original magnification × 400). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Case 2. (A) Chest computed tomography scan showing right lung tumor with massive pleural effusion. (B) The first biopsy showed an adenocarcinoma (hematoxylin and eosin stain, original magnification × 200) immunoreactive to thyroid transcription factor-1 (inset, original magnification × 400). (C) The second biopsy of the right pleural mass showed a squamous cell carcinoma (hematoxylin and eosin stain, original magnification × 200), which was p40(+) (inset, original magnification × 400) and (D) strongly immunoreactive to anti-epidermal growth factor receptor L858R antibodies (original magnification × 400). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

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