1. Immune thrombocytopenic purpura (ITP)
Ali Al Khader, M.D.
Faculty of Medicine
Al-Balqa’ Applied University

2. ITP 2 clinical subtypes 1-Chronic…relatively common
…women between 20 & 40
2-Acute…self-limited
…mostly in children after viral infection

3. Chronic ITP
Antibodies against platelet membrane glycoproteins IIb/IIIa or Ib/IX
…detected in roughly 80% of cases of chronic ITP
The spleen is an important site of:
-anti-platelet antibody production
-destruction of the IgG-coated platelets
The bone marrow usually contains increased numbers of megakaryocytes
…a finding common to all forms of thrombocytopenia caused by
accelerated platelet destruction

4. Chronic ITP, clinical features
Petechiae, easy bruising, epistaxis, gum bleeding, and hemorrhages
after minor trauma
…more serious intracerebral or subarachnoid hemorrhages are
uncommon

5. ITP, diagnosis Clinical features The presence of thrombocytopenia
Examination of the marrow
The exclusion of secondary ITP…due to drugs or autoimmune disease

6. Chronic ITP, treatment
Treatment usually involves the use of immunosuppressive agents and, in some cases, splenectomy
Splenomegaly is not a feature of uncomplicated chronic ITP
…However, splenectomy:
…normalizes the platelet count
…induces a complete remission in more than two-thirds of
patients

7. Thank You