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Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment  A. Andersson, M. Rundgren, S. Kalman,

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Presentation on theme: "Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment  A. Andersson, M. Rundgren, S. Kalman,"— Presentation transcript:

1 Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment  A. Andersson, M. Rundgren, S. Kalman, O. Rooyackers, O. Brattstrom, A. Oldner, S. Eriksson, R. Frithiof  British Journal of Anaesthesia  Volume 108, Issue 2, Pages (February 2012) DOI: /bja/aer379 Copyright © 2012 The Author(s) Terms and Conditions

2 Fig 1 Microcirculatory blood flow in the muscularis layer (MCQmusc), microcirculatory blood flow in the mucosa (MCQmuc), mean arterial pressure (MAP), and superior mesenteric artery flow indexed to bodyweight (SMAFI) in the endotoxin group (open squares, n=6–8) and sham animals (filled circles, n=4–5). Data are presented as mean (sd). *P<0.05 significant difference for change over time from 0 to 24 h in the endotoxin group. #P<0.05 significant difference for change over time from 24 to 25 h in the endotoxin group. British Journal of Anaesthesia  , DOI: ( /bja/aer379) Copyright © 2012 The Author(s) Terms and Conditions

3 Fig 2 SDF-derived variables and mucosal-arterial Pco2-gap in the endotoxin group. MFI, microvascular flow index; HI, heterogeneity index; PV%, percentage of perfused villi; Pco2 muc-art, mucosal-arterial Pco2-gap. Data are presented as median [interquartile range]. *P<0.05 significant difference for change over time from 0 to 24 h. n=7. In sham animals, these parameters remained stable over time, and for the sake of clarity this group was not included in the figure. British Journal of Anaesthesia  , DOI: ( /bja/aer379) Copyright © 2012 The Author(s) Terms and Conditions

4 Fig 3 Individual values for change in complex I (mitochondrial complex I activity, µmol min−1 g wet weight−1) and complex I/CS (the ratio of complex I activity to citrate synthase activity) between 24 and 25 h in the endotoxin group. British Journal of Anaesthesia  , DOI: ( /bja/aer379) Copyright © 2012 The Author(s) Terms and Conditions

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