1. Updates in Heart Failure:

2. Foxglove

3. William Withering on Dose-Response of Digoxin

4. Learning Objectives

5. Unfortunately There is a Downside To Calcium Loading of Cells

6. PROVED/RADIANCE: No Added Benefit of High vs Low SDC on Worsening HF

8. Association of Serum Digoxin Concentration With Hospitalization Risk

9. DIG Trial: Significant Reduction in CHF Hospitalizations But No Effect on Mortality

10. Post Hoc DIG Trial SDC and Mortality

11. Survival Curves of Women Placebo vs High and Low Digoxin Serum Levels

12. Summary Clinical Points to Consider

13. Abbreviations

14. Abbreviations (cont)

15. References

16. References (cont)