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Influence of equianaesthetic concentrations of nitrous oxide and isoflurane on regional cerebral blood flow, regional cerebral blood volume, and regional.

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Presentation on theme: "Influence of equianaesthetic concentrations of nitrous oxide and isoflurane on regional cerebral blood flow, regional cerebral blood volume, and regional."— Presentation transcript:

1 Influence of equianaesthetic concentrations of nitrous oxide and isoflurane on regional cerebral blood flow, regional cerebral blood volume, and regional mean transit time in human volunteers  I.H. Lorenz, C. Kolbitsch, C. Ho¨rmann, T.J. Luger, M. Schocke, S. Felber, F. Zschiegner, M. Hinteregger, C. Kremser, A. Benzer  British Journal of Anaesthesia  Volume 87, Issue 5, Pages (November 2001) DOI: /bja/ Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Representative CBV map during administration of isoflurane (0.4 MAC) showing regions of interest for evaluation of right hemisphere white matter and parietal (gm parietal), frontal (gm frontal) (a), thalamic (thalamus), striatal (striatum) and occipital (gm occipital) (b) grey matter rCBV. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

3 Fig 1 Representative CBV map during administration of isoflurane (0.4 MAC) showing regions of interest for evaluation of right hemisphere white matter and parietal (gm parietal), frontal (gm frontal) (a), thalamic (thalamus), striatal (striatum) and occipital (gm occipital) (b) grey matter rCBV. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

4 Fig 2 rCBF in white matter (WM) and grey matter [striatal (GM_ST), thalamic (GM_TH), frontal (GM_FR), parietal (GM_PA), occipital (GM_OC)] during control and administration of isoflurane (0.4 MAC) (n=9) (a) and during control and administration of nitrous oxide (0.4 MAC) (n=9) (b). Data are presented as boxplots [e.g. median (upper, lower quartiles; range]. *P<0.05. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

5 Fig 3 rCBV in white matter (WM) and grey matter [striatal (GM_ST), thalamic (GM_TH), frontal (GM_FR), parietal (GM_PA), occipital (GM_OC)] during control and administration of isoflurane (0.4 MAC) (n=9) (a) and during control and administration of nitrous oxide (0.4 MAC) (n=9) (b). Data are presented as boxplots [e.g. median (upper, lower quartiles; range)]. *P<0.05. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

6 Fig 4 rMTT in white matter (WM) and grey matter [striatal (GM_ST), thalamic (GM_TH), frontal (GM_FR), parietal (GM_PA), occipital (GM_OC)] during control and administration of isoflurane (0.4 MAC) (n=9) (a) and during control and administration of nitrous oxide (0.4 MAC) (n=9) (b). Data are presented as boxplots [e.g. median (upper, lower quartiles; range)]. *P<0.05. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

7 Fig 5 Percentage changes in rCBF in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean ± sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

8 Fig 5 Percentage changes in rCBF in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean ± sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

9 Fig 6 Percentage changes in rCBFV in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean ± sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

10 Fig 6 Percentage changes in rCBFV in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean ± sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

11 Fig 7 Percentage changes in rMTT in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean and sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

12 Fig 7 Percentage changes in rMTT in frontal, parietal, occipital grey matter (a) and in striatal and thalamic grey matter and in white matter (b) during administration of isoflurane (0.4 MAC) (n=9) or nitrous oxide (0.4 MAC) (n=9). Data are mean and sem. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions


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