1. Tumour‐induced IL6 increases systemic cholesterol levels
Tumour‐induced IL6 increases systemic cholesterol levels ARelative quantitation of human HMGCR mRNA in the indicated CWR22Res orthografts (n = 3 mice per group; *P < 0.05 ANOVA Tukey's test).B–ETotal cholesterol (B, D) and IL6 (C, E) in sera from mice with CWR22Res prostate orthografts (n = 5 mice per group; *P < 0.05 ANOVA Tukey's test).FSerum levels of human IL6 in patients with hormone‐naïve (n = 172) or castration‐resistant (n = 129) form of prostate cancer (*P = 0.0002; unpaired two‐tailed t‐test with Welch's correction).GScatter plot showing correlation of serum levels of PSA and IL6 from prostate cancer patients.HKaplan–Meier plot for overall (post‐diagnosis) survival of CRPC patients with no evidence of metastases (M0) segregated based on above median (high) and below median (low) serum levels of IL6 (high IL6 = 9; low IL6 = 7; log‐rank Mantel–Cox test; P = 0.004).I, JThe epididymal fat weights of mice bearing indicated CWR22Res orthografts (n = 5 mice per group; *P < 0.05 ANOVA Tukey's test).KRepresentative immunoblot image for perilipin in epididymal adipose tissue lysates from mice with CWR22Res prostate orthografts.L, MFree fatty acids in sera from mice with indicated CWR22Res prostate orthografts (n = 5 mice per group; *P < 0.05 ANOVA Tukey's test).NScatter plot showing correlation of serum levels of IL6 and free fatty acids (FFAs) from prostate cancer patients.Data Information: In (A–G, I, J, L–N), each data point represents one independent observation. In (A–E; I, J, L, M), the data are presented as mean ± SD.Source data are available online for this figure.
Rachana Patel et al. EMBO Mol Med. 2018;emmm
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