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Does short bowel syndrome increase the risk of food allergy and eosinophilic gastrointestinal disease? Observations in Shah-Waardenburg syndrome  Evelyn.

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Presentation on theme: "Does short bowel syndrome increase the risk of food allergy and eosinophilic gastrointestinal disease? Observations in Shah-Waardenburg syndrome  Evelyn."— Presentation transcript:

1 Does short bowel syndrome increase the risk of food allergy and eosinophilic gastrointestinal disease? Observations in Shah-Waardenburg syndrome  Evelyn Leechawengwongs, MD, Brian E. Tison, MD, G.S. Gopalakrishna, MD, Barbara S. Reid, MD, Carlos A. Bacino, MD, Andrea L. Haws, MD, MS, Milton J. Finegold, MD, William T. Shearer, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 131, Issue 1, Pages (January 2013) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Patient 1: 10-year-old girl with SWS and SBS. A, Extensive hypopigmentation of the skin throughout the face and scalp, areas of white hair, and light blue irides. B, Back of torso displaying placement of environmental and food allergens (15 minutes after inoculation). C, Hematoxylin and eosin–stained section of esophageal mucosa showing eosinophilic infiltrates (original magnification ×10). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 Patient 1: 10-year-old girl with SWS and SBS. A, Extensive hypopigmentation of the skin throughout the face and scalp, areas of white hair, and light blue irides. B, Back of torso displaying placement of environmental and food allergens (15 minutes after inoculation). C, Hematoxylin and eosin–stained section of esophageal mucosa showing eosinophilic infiltrates (original magnification ×10). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 2 Patient 2: 14-year-old boy with SWS and SBS. A, Striking generalized hypopigmentation of the skin, white eyebrows, a couple of small white forelocks, and blue irides. B, Small bowel with 75 eosinophils/hpf (circled) and focal acute inflammation in the surface epithelium (original magnification ×10). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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