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Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection 

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Presentation on theme: "Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection "— Presentation transcript:

1 Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection  Timothy D Planche, MD, Kerrie A Davies, MSc, Pietro G Coen, DPhil, John M Finney, BSc, Irene M Monahan, PhD, Kirsti A Morris, PhD, Lily O'Connor, BSc, Sarah J Oakley, MSc, Cassie F Pope, PhD, Mike W Wren, PhD, Nandini P Shetty, FRCPath, Prof Derrick W Crook, MB BCh, Prof Mark H Wilcox, MD  The Lancet Infectious Diseases  Volume 13, Issue 11, Pages (November 2013) DOI: /S (13) Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Patient and sample selection
CC=cytotoxigenic culture. CTA=cytotoxin assay. The Lancet Infectious Diseases  , DOI: ( /S (13) ) Copyright © 2013 Elsevier Ltd Terms and Conditions

3 Figure 2 AUROCs (median and 95% CI) for each individual assay and algorithms (A) Comparison with the cell cytotoxicity reference method. (B) Comparison with the cytotoxigenic culture reference method. Comparisons were done in the training phase. Error bars represent 95% CIs. AUROC= area under the receiver operator characteristic curve. GDH=glutamate dehydrogenase. The Lancet Infectious Diseases  , DOI: ( /S (13) ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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