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Association of the CHRNA3 Locus with Lung Cancer Risk and Prognosis in Chinese Han Population  Xiaomin Niu, MD, Zhiwei Chen, MD, PhD, Shengping Shen,

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Presentation on theme: "Association of the CHRNA3 Locus with Lung Cancer Risk and Prognosis in Chinese Han Population  Xiaomin Niu, MD, Zhiwei Chen, MD, PhD, Shengping Shen,"— Presentation transcript:

1 Association of the CHRNA3 Locus with Lung Cancer Risk and Prognosis in Chinese Han Population 
Xiaomin Niu, MD, Zhiwei Chen, MD, PhD, Shengping Shen, MD, Yun Liu, PhD, Daizhan Zhou, PhD, Jie Zhang, MD, PhD, Ziming Li, MD, Yongfeng Yu, MD, Meilin Liao, MD, Shun Lu, MD, PhD, Lin He, PhD  Journal of Thoracic Oncology  Volume 5, Issue 5, Pages (May 2010) DOI: /JTO.0b013e3181d5e447 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Patients distribution.
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d5e447) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Linkage disequilibrium (LD) structure at 15q25 in individuals in CHB (Han Chinese in Beijing, China). Boxes are shaded according to D′ derived in Haploview (v4.0). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d5e447) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Linkage disequilibrium (LD) structure of the single nucleotide polymorphism (SNP) in CHRNA3 (D′/r2 value). Pairwise D′ values are color coded: high D′ values are dark, low D′ values are light (values were generated by SHEsis software16). The numbers shown at the top represent the degrees of the location of the region on chromosome 15 (Chr 15). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d5e447) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Kaplan-Meier survival curves about rs genotype in 122 patients with advanced stage non-small cell lung cancer (NSCLC). The curves of patients with CHRNA3 genotype TT (n = 20), TG + GG (n = 102) were shown as blue and green lines, respectively. Follow-up was shown truncated at 21 months. Log-rank analysis indicated significant differences between OS curves (p = 0.037). OS, overall survival; MST, median survival time; NR, not reach. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d5e447) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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