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Volume 144, Issue 4, Pages (April 2013)

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1 Volume 144, Issue 4, Pages 781-788 (April 2013)
A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn's Disease in a Japanese Population  Keiko Yamazaki, Junji Umeno, Atsushi Takahashi, Atsushi Hirano, Todd Andrew Johnson, Natsuhiko Kumasaka, Takashi Morizono, Naoya Hosono, Takaaki Kawaguchi, Masakazu Takazoe, Tetsuhiro Yamada, Yasuo Suzuki, Hiroki Tanaka, Satoshi Motoya, Masayo Hosokawa, Yoshiaki Arimura, Yasuhisa Shinomura, Toshiyuki Matsui, Takayuki Matsumoto, Mitsuo Iida, Tatsuhiko Tsunoda, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo  Gastroenterology  Volume 144, Issue 4, Pages (April 2013) DOI: /j.gastro Copyright © 2013 AGA Institute Terms and Conditions

2 Figure 1 The result of the GWAS for CD. Manhattan plot for 453,099 SNPs from the GWAS for CD. SNPs are plotted according to chromosomal location, with the −log10(P) calculated by the Cochran–Armitage test. The red line indicates the significance threshold for the GWAS (P = 5.0 × 10−8). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

3 Figure 2 Case-control association results, LD map, and genomic structure of the regions on chromosomes (A) 4p14 and (B) 13q14. High-density mapping was performed in the regions (A) from to Mb on 4p14 and from (B) to 41.8 Mb on 13q14. The black dots represent genotyped SNPs, and gray dots represent imputed SNPs. The thick black line represents the associated region defined by the LD block. The LD map based on D-prime values was drawn by using the genotype data of high-density mapping with markers of MAF greater than 0.2. The landmark SNPs on each region are indicated by a red line. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions


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