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Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled.

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Presentation on theme: "Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled."— Presentation transcript:

1 Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial  C. Conrad, J. Lymp, V. Thompson, C. Dunn, Z. Davies, B. Chatfield, D. Nichols, J. Clancy, R. Vender, M.E. Egan, L. Quittell, P. Michelson, V. Antony, J. Spahr, R.C. Rubenstein, R.B. Moss, L.A. Herzenberg, C.H. Goss, R. Tirouvanziam  Journal of Cystic Fibrosis  Volume 14, Issue 2, Pages (March 2015) DOI: /j.jcf Copyright © Terms and Conditions

2 Fig. 1 Flow diagram of participants.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

3 Fig. 2 Mean change from baseline in FEV1 (L) over time by treatment group. The 95% confidence intervals are calculated using one-sample t-tests. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

4 Fig. 3 Kaplan–Meier plot of time to pulmonary exacerbation.
Censored subjects are denoted with ‘tick’ marks. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions


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