Presentation is loading. Please wait.

Presentation is loading. Please wait.

The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model  Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi.

Published byArnoldo Salvatori Modified over 5 years ago

Similar presentations

Presentation on theme: "The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model  Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi."— Presentation transcript:

1 The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model  Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi Tanaka, MD, Teruo Yamashita, MD, Keitaro Nakagiri, MD, Yutaka Okita, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 133, Issue 6, Pages (June 2007) DOI: /j.jtcvs Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Schematic representation of the animal model for spinal cord ischemia with back-bleeding from lumbar arteries (group 1). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Consecutive changes of blood pressure in group 1 (open triangle) and group 2 (open circle). A, Systolic and diastolic arterial pressure. B, Mean arterial pressure. The “declamp” pressure was measured immediately after aortic unclamping, and the “last” pressure was measured after skin closure, which took approximately 5 minutes after aortic unclamping in each animal. Repeated measures ANOVA and Mann–Whitney test showed no significant difference between group 1 and group 2 at each pressure. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Neurologic scores with MTS in each group (black bar, group 1; gray bar, group 2; open bar, group 3) at 4, 24, and 48 hours after operation. All values are presented as the mean ± standard deviation of the Kruskal–Wallis test and Scheffe multiple comparison test. MTS, modified Tarlov scale. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Photomicrographs of histologic sections in the rabbit spinal cord at 48 hours of reperfusion after 15 minutes of ischemia. Hematoxylin and eosin staining in the ventral gray matter of group 1 (A) and group 2 (C). The spinal cords show necrotic change, including destruction and vacuolization of the gray matter, pyknosis of neurons, and eosinophilic changes of the cytoplasm (A and C). TUNEL staining in the ventral gray matter of group 1 (B) and group 2 (D). Arrows show motor neuron cell nuclei positive with TUNEL staining. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 The number of normal motor neuron and TUNEL-positive cells in each group at 4 and 48 hours after the procedures. All values are presented as the mean ± standard deviation. Black, gray, and open bars represent group 1, group 2, and group 3, respectively. Kruskal–Wallis test and Scheffe multiple comparison test. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model  Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi."

Similar presentations

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.
Lost in translation The Journal of Thoracic and Cardiovascular Surgery

Lost in translation The Journal of Thoracic and Cardiovascular Surgery
Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries  Joseph S. Giglia, MD, Gerald B. Zelenock,

Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries  Joseph S. Giglia, MD, Gerald B. Zelenock,
Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia  Fang He, MD, Enyi Shi, MD, PhD, Lihui Yan, MD, Juchen.

Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia  Fang He, MD, Enyi Shi, MD, PhD, Lihui Yan, MD, Juchen.
Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion  Ioannis K. Toumpoulis,

Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion  Ioannis K. Toumpoulis,
Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion  Ioannis K. Toumpoulis,

Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion  Ioannis K. Toumpoulis,
Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia  Enyi Shi, MD, PhD, Xiaojing.

Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia  Enyi Shi, MD, PhD, Xiaojing.
Ischemic postconditioning protects the spinal cord from ischemia–reperfusion injury via modulation of redox signaling  Wenying Song, MD, Jing Sun, MD,

Ischemic postconditioning protects the spinal cord from ischemia–reperfusion injury via modulation of redox signaling  Wenying Song, MD, Jing Sun, MD,
Oxygenation of the cerebrospinal fluid with artificial cerebrospinal fluid can ameliorate a spinal cord ischemic injury in a rabbit model  Keisuke Kanda,

Oxygenation of the cerebrospinal fluid with artificial cerebrospinal fluid can ameliorate a spinal cord ischemic injury in a rabbit model  Keisuke Kanda,
Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administration  Hitoshi Terada, MD, Teruhisa Kazui, MD, Makoto.

Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administration  Hitoshi Terada, MD, Teruhisa Kazui, MD, Makoto.
Influence of Perioperative Hemodynamics on Spinal Cord Ischemia in Thoracoabdominal Aortic Repair  Yujiro Kawanishi, MD, Kenji Okada, MD, Masamichi Matsumori,

Influence of Perioperative Hemodynamics on Spinal Cord Ischemia in Thoracoabdominal Aortic Repair  Yujiro Kawanishi, MD, Kenji Okada, MD, Masamichi Matsumori,
Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits  Hironori Baba, MD, Yoshihisa Tanoue, MD, PhD, Taketoshi.

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits  Hironori Baba, MD, Yoshihisa Tanoue, MD, PhD, Taketoshi.
Loic Lang-Lazdunski, MDa,b. , Catherine Heurteaux, PhDb

Loic Lang-Lazdunski, MDa,b. , Catherine Heurteaux, PhDb
Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis  Hiroyuki Kato, MD, PhDa c, Georgios.

Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis  Hiroyuki Kato, MD, PhDa c, Georgios.
Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole  Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.

Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole  Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.
Surgical Results of Acute Aortic Dissection Complicated With Cerebral Malperfusion  Hiroshi Tanaka, MD, Kenji Okada, MD, Teruo Yamashita, MD, Yoshihisa.

Surgical Results of Acute Aortic Dissection Complicated With Cerebral Malperfusion  Hiroshi Tanaka, MD, Kenji Okada, MD, Teruo Yamashita, MD, Yoshihisa.
Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.
Erythropoietin protects the central nervous system during prolonged hypothermic circulatory arrest: An experimental study in a canine model  Mitsuhiro.

Erythropoietin protects the central nervous system during prolonged hypothermic circulatory arrest: An experimental study in a canine model  Mitsuhiro.
The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation  T.

The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation  T.
Experimental study on the protective effects of edaravone against ischemic spinal cord injury  Kazuchika Suzuki, MD, Teruhisa Kazui, MD, PhD, Hitoshi.

Experimental study on the protective effects of edaravone against ischemic spinal cord injury  Kazuchika Suzuki, MD, Teruhisa Kazui, MD, PhD, Hitoshi.

Similar presentations

Ads by Google