1. The intermittent hypoxia model in normal volunteers.
The intermittent hypoxia model in normal volunteers. Subjects were exposed to a low inspiratory oxygen fraction (13%) and were maintained at an arterial oxygen saturation measured by pulse oximetery (Sp,O2) of 92% using oxygen nasal flow delivery, which was stopped every 120 s for 20 s. This produced 30 oxygen desaturations per hour. Representive nocturnal oxymetric traces of a) an obstructive sleep apnoea (OSA) patient over 8 h, b) a healthy subject exposed to intermittent hypoxia for 6 h, c) an OSA patient for 30 mins and d) a healthy subject exposed to intermittent hypoxia for 50 mins. e) The setting for intermittent hypoxia in healthy subjects.
P. Lévy et al. Eur Respir Rev 2011;20:
©2011 by European Respiratory Society