1. Window of Opportunity in RA
Radiographic progression occurs early and continues over the lifetime of a patient
70% of patients have radiographic damage within the first 3 years
PCP
800,000
Rheums
725,000
Severe functional decline
Radiographic damage
Work disability
Premature death
Disease onset ♀
Zhu A&R 2011;63: Zhang. ARD 2013 Jan 23 Taylor. Am J Med. 2012;125:1126
Zhang. A&R 2012;64:4004 Choi H. BMJ. 2012;12;344 Kuo CF. Joint Bone Spine. 2012;79:375.
DeVera Arthritis Rheum. 2008;59:1549
Critical window of opportunity
O’Dell JR. Arthritis Rheum. 2002;46: Editorial.
Landewe RBM, et al. Arthritis Rheum. 2002;46: