1. Ovarian cancer cells harbour numerous copy number alterations unlinked to drug‐induced cell death
Ovarian cancer cells harbour numerous copy number alterations unlinked to drug‐induced cell death ACopy number alterations (CNAs) in primary ovarian cancer (OC) cell lines used for DeathPro drug screening. CNAs were determined from whole‐genome sequencing data. Losses are shown in blue, gains in red.B>Panel of 29 OC‐relevant genes depicting patient cell line‐specific gains, losses including loss of heterozygosity, indels and somatic nucleotide variations (SNVs) in coding regions. Genes were selected from COSMIC and ICGC databases.C–FAssociation of copy number changes in drug target genes with drug sensitivities. (C) Cytotoxicity of Aurora kinase A inhibitor MK5108 in patients with or without (WT) AURKA amplification. (D) Cytotoxicity of PI3K inhibitor BKM120 in patients with or without (WT) PI3KCA gain. (E, F) Cytotoxicity induced by carboplatin (E) or olaparib (F) in patients with or without (WT) BRCA1 or BRCA2 loss. Two‐sided Welch's t‐test was performed.
Julia Jabs et al. Mol Syst Biol 2017;13:955
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