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Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined.

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Presentation on theme: "Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined."— Presentation transcript:

1 Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies  A. Antoniou, P.D.P. Pharoah, S. Narod, H.A. Risch, J.E. Eyfjord, J.L. Hopper, N. Loman, H. Olsson, O. Johannsson, Å. Borg, B. Pasini, P. Radice, S. Manoukian, D.M. Eccles, N. Tang, E. Olah, H. Anton-Culver, E. Warner, J. Lubinski, J. Gronwald, B. Gorski, H. Tulinius, S. Thorlacius, H. Eerola, H. Nevanlinna, K. Syrjäkoski, O.-P. Kallioniemi, D. Thompson, C. Evans, J. Peto, F. Lalloo, D.G. Evans, D.F. Easton  The American Journal of Human Genetics  Volume 72, Issue 5, Pages (May 2003) DOI: /375033 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Kaplan-Meier cumulative breast (upper lines) and ovarian (lower lines) cancer probability in sisters (thick lines) and mothers (thin lines) of BRCA1-mutation–carrying index case patients. The American Journal of Human Genetics  , DOI: ( /375033) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Kaplan-Meier cumulative breast (upper lines) and ovarian (lower lines) cancer probability in sisters (thick lines) and mothers (thin lines) of BRCA2-mutation–carrying index case patients. The American Journal of Human Genetics  , DOI: ( /375033) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

4 Figure 3 Cumulative risk of breast (♦) and ovarian (▪) cancer in BRCA1-mutation carriers. The American Journal of Human Genetics  , DOI: ( /375033) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

5 Figure 4 Cumulative risk of breast (♦) and ovarian (▪) cancer in BRCA2-mutation carriers. The American Journal of Human Genetics  , DOI: ( /375033) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

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