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Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol,

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Presentation on theme: "Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol,"— Presentation transcript:

1 Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity  Christian Abendstein Kjellmo, MD, Helen Karlsson, PhD, Torunn K. Nestvold, MD, PhD, Stefan Ljunggren, PhD, Karin Cederbrant, PhD, Maritha Marcusson-Ståhl, BSc, Monica Mathisen, BLS, Knut Tore Lappegård, MD, PhD, Anders Hovland, MD, PhD  Journal of Clinical Lipidology  Volume 12, Issue 1, Pages (January 2018) DOI: /j.jacl Copyright © 2017 National Lipid Association Terms and Conditions

2 Figure 1 Serum levels of (A) LDL cholesterol, (B) HDL cholesterol, (C) triglycerides (TGs), and (D) apoB at inclusion, after a lifestyle intervention (∼3 months) and 1 year after bariatric surgery in 34 morbidly obese patients, and at inclusion for controls. Values are mean with standard deviation. *P < .05, **P < .01, ***P < .001, ****P < .0001, ns, not statistically significant. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2017 National Lipid Association Terms and Conditions

3 Figure 2 Serum levels of the (A) large, boyant LDL (lbLDL) subfractions, (B) the small, dense LDL (sdLDL) subfractions, (C) large HDL subfractions, (D) small HDL subfractions at inclusion, after a lifestyle intervention (∼3 months) and 1 year after bariatric surgery in 34 morbidly obese patients, and at inclusion for controls. Values are mean with standard deviation. *P < .05, **P < .01, ***P < .001, ****P < .0001, ns, not statistically significant. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2017 National Lipid Association Terms and Conditions

4 Figure 3 A) Cholesterol efflux capacity (CEC), (B) Serum paraoxonase-1 (PON1) activity, and (C) serum amyloid A1/PON1 (SAA/PON1) ratio determined at inclusion, after a lifestyle intervention (∼3 months) and 1 year after bariatric surgery in 34 morbidly obese patients, and at inclusion for controls. Values are mean with standard deviation. *P < .05, **P < .01, ***P < .001, ****P < .0001, ns, not statistically significant. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2017 National Lipid Association Terms and Conditions

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