1. Supplementary Figure 4 a b c d e f
NES 1.780
NOM p-val 0.001
FDR q-val 0.006
NES 1.524
NOM p-val
FDR q-val 0.053 c d
BC-1
GTO
41.6%
58.4%
Relative XAF1 mRNA
Relative XAF1 mRNA e f
BC-1
GTO
BC-1
GTO
Relative OAS1 mRNA
Relative OAS1 mRNA
Relative TRAIL mRNA
Relative TRAIL mRNA
Supplementary Figure 4. GSEA plots revealing significant positive enrichment of gene expression signatures of apoptosis (a) and p53 pathway (b) derived from a database ( in PU.1-up-regulated BCBL-1 cells compared with control cells. (c) The ratio of up-regulated ISGs among at least two-fold increased genes in the microarray analysis. XAF1 (d), OAS1 (e), and TRAIL (f) mRNA expression levels were measured by quantitative RT-PCR. BC-1 and GTO cells that expressed Dox-inducible PU.1 were treated with 1.0 μg/ml Dox for 0, 24, and 48 h. Values are the mean ± SD (n =3).