1. The Power of Silence: Application of Small Interfering RNAs to Gastrointestinal Diseases 
Ella H. Sklan, Jeffrey S. Glenn 
Gastroenterology 
Volume 132, Issue 7, Pages (June 2007)
DOI: /j.gastro
Copyright © 2007 AGA Institute Terms and Conditions

2. Figure 1
Molecular mechanism of the siRNA pathway. Short interfering RNAs produced by Dicer, or synthetically synthesized and inserted into the cell, are incorporated into the RISC complex. The strands are separated and RISC assembles into an activated complex, which seeks its target mRNAs. Once identified, the target is cleaved by AGO2 (a RISC component) and the RISC is recycled to enable cleavage of an additional target.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

3. Figure 2
Prospective targets in the digestive system. Digestive organ targets to which siRNAs have been prepared and tested in tissue culture or animal models. Several of these strategies are currently in various stages of preclinical and early clinical evaluation.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions