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Triglyceride Metabolism under Attack

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1 Triglyceride Metabolism under Attack
Sander Kersten  Cell Metabolism  Volume 25, Issue 6, Pages (June 2017) DOI: /j.cmet Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Autoantibodies against GPIHBP1 Provoke Hyperchylomicronemia
Left panel: metabolism of triglyceride-rich lipoproteins under normal circumstances. LPL is produced by adipocytes and myocytes and transported from the surface of these cells to the capillary lumen by GPIHBP1. Right panel: autoantibodies against GPIHBP1 prevent the transport of LPL to the capillary lumen. The resultant functional LPL deficiency leads to impaired clearance of triglyceride-rich lipoproteins, causing hyperchylomicronemia. LPL, lipoprotein lipase; GPIHBP1, glycosylphosphatidylinositol-anchored HDL binding protein 1; HSPG, heparan sulfate proteoglycan; TG, triglycerides. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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