1. Total Synthesis of (-)-Conophylline
By Daniela Sustac
Han-Ya, Y.; Tokuyama, H.; Fukuyama, T. Angew. Chem. Int. Ed. 2011, 50, 4884.

2. Introduction Isolated in 1992 (Tabernaemontana divaricata)
Potential use in type I diabetes and cancer therapy;
Bis(indole) alkaloid, unique furan connectivity between the two fragments.

3. Retrosysnthesis

4. Synthesis of Fragment A

5. Fragment A - continued

6. Synthesis of Amine
Fukuyama JACS 2002, 124, 2137.

7. Fragment A - continued

8. Fragment A – done!

9. Fragment B

10. Fragments coupling

11. Previous studies
JOC 1982, 47, 803.

12. Last Steps