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Published byChrister Jansen Modified over 6 years ago
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Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis
Aaron M. Hosios, Matthew G. Vander Heiden Developmental Cell Volume 40, Issue 2, Pages (January 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions
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Figure 1 Sources and Uses of Acetyl-CoA in Mammalian Cells
Fatty acids, glucose, amino acids, and acetate can all serve as sources of acetyl-CoA. To produce acetyl-CoA from fatty acids, fatty acyl-CoA must be transported into the mitochondrial matrix, requiring enzymes CPT1 and CPT2, as shown. Fatty acyl-CoA in the mitochondrial matrix can undergo β-oxidation to produce acetyl-CoA. Mitochondrial acetyl-CoA can enter the TCA cycle to be further oxidized to CO2 for energy generation, or it can be exported to the cytosol (as citrate) for use in biosynthesis or for acetylation reactions. Developmental Cell , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions
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