1. Lecture 16 Web: pollev.com/ucibio Text: To: 37607
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2. Energy generation overview

3. Cellular compartments
Where does Glycolysis occur?
Cytosol
Where does TCA occur?
Mitochondria

4. Cellular compartments

5. Pyruvate  Acetyl CoA

6. What’s CoA?

7. Pyruvate  Acetyl CoA

8. Pyruvate  Acetyl CoA

9. Pyruvate  Acetyl CoA

10. Regulation layer one: Within cell

11. Regulation layer two: Signaling

12. Sound familiar? Nicotinic acid  NAD Riboflavin  FAD
Pantothenic acid  CoA
Biotin
VITAMINS!

13. Vitamins are metabolic cofactors
Give rise to different “carriers”
Need small amounts – cyclic!

14. Energy generation overview

15. The TCA

16. TCA Regulation

17. TCA Regulation

18. TCA Regulation

19. TCA Regulation

20. TCA energy production

21. TCA energy production

22. TCA energy production

23. Glucose energy production