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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 133, Issue 5, Pages (November 2007) DOI: /j.gastro Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Changes in pain intensity scores (left panel) and pain frequency scores (right panel) during and after treatment with SMT or HT in childhood FAP or IBS. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Study design and protocol-defined outcomes through 96 weeks. Patients entered the second year of treatment with lamivudine (LVD) or entecavir (ETV) at week 52, based on the results of week 48 HBV DNA and HBeAg status. R, responder [HBV DNA <0.7 mEq/mL and HBeAg(−)]; VR, virologic responder (HBV DNA <0.7 mEq/mL and HBeAg[+]); NR, nonresponder (HBV DNA ≥0.7 mEq/mL). Only virologic responders continued blinded therapy into the second year. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions

4 Figure 3 Inhibitory effect of yeast mannan on bacterial killing by normal adherent human monocytes. Mannan, at 1 mg/mL, inhibits killing of control E coli ATCC and Crohn’s disease mucosa-associated E coli HM605 (n = 10) by normal adherent monocytes. E coli HM605 is shown to be more resistant to killing than E coli ATCC (P = .03). Mannan had a similar effect on the killing of S aureus by adherent monocytes. Data are presented as mean ± SEM. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions

5 Figure 4 Progastrin stimulates β-catenin/Tcf-4 activity in human colorectal cancer cells. (A) Tcf-4 transcriptional activity was quantified using the TOP/FOP luciferase reporter gene assay in untreated SW480/bgal(−) and SW480/GAST(−) cells (clones [1] and [2]; black bars), or in the same cells treated with 5 nmol recombinant progastrin for 72 hours (rPG; light grey bars), or transfected with a shRNA-insensitive preprogastrin cDNA (cPG; dark grey bars). Value are means ± SEM of 4 similar experiments (*P < .05 compared with SW480/GAST(−) cells). (B) Independent and overlaid confocal images of β-catenin (green), Tcf-4 (red), and DAPI (blue) in SW480/bgal(−) cells and SW480/GAST(−) cells with or without 5 nmol progastrin treatment for 72 hours. Bars represent 40 μm. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions


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