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DNA Polymerases at the Replication Fork in Eukaryotes

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1 DNA Polymerases at the Replication Fork in Eukaryotes
Bruce Stillman  Molecular Cell  Volume 30, Issue 3, Pages (May 2008) DOI: /j.molcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Comparison of SV40 and Cellular Replication Forks
(A) DNA replication fork showing the proteins required for replication of SV40 DNA. (B) Replication forks emerging from cellular origins of DNA replication are established by Pol α/primase, but in this case Pol ɛ synthesizes the leading strand and Pol δ the lagging strand. Instead of T antigen to unwind the DNA, helicase activity is provided by the Cdc45-MCM-GINS (CMG) complex. Many proteins certainly involved are not shown here. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions


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