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Michelle Nisolle, M. D. , Ph. D. , Françoise Casanas-Roux, B. S

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Presentation on theme: "Michelle Nisolle, M. D. , Ph. D. , Françoise Casanas-Roux, B. S"— Presentation transcript:

1 Early-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice 
Michelle Nisolle, M.D., Ph.D., Françoise Casanas-Roux, B.S., Jacques Donnez, M.D., Ph.D.  Fertility and Sterility  Volume 74, Issue 2, Pages (August 2000) DOI: /S (00)

2 Figure 1 Human endometrial implant on day 1. Human stromal cells are already found to be attached ( ) to the peritoneum. Normal mesothelium is found beneath stromal cells ( ). (Stain, Gomori’s trichrome; original magnification, ×40). Fertility and Sterility  , DOI: ( /S (00) )

3 Figure 2 Human endometrial implant on day 3. (A), Early invasion of stromal cells in the submesothelial area (between the arrows). (Stain, Gomori’s trichrome; original magnification, ×25). (B), Typical cylindrical glandular cells are noted (black arrow) in some areas but, obviously, invasion is due to stromal cells. (Stain, Gomori’s trichrome; original magnification, ×25). Fertility and Sterility  , DOI: ( /S (00) )

4 Figure 3 Human endometrial implant on day 5. (A), Dilated and nondilated endometriotic glands surrounded by stromal cells are clearly present in the submesothelial fatty tissue. (A), Stain, Gomori’s trichrome; original magnification, ×10). (B), Numerous well-formed endometriotic glands are noted. (Stain, Gomori’s trichrome; original magnification, ×40). Fertility and Sterility  , DOI: ( /S (00) )


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