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Huy X. Ngo, Sylvie Garneau-Tsodikova  Structure 

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Presentation on theme: "Huy X. Ngo, Sylvie Garneau-Tsodikova  Structure "— Presentation transcript:

1 Flipping the Switch “On” for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed! 
Huy X. Ngo, Sylvie Garneau-Tsodikova  Structure  Volume 24, Issue 7, Pages (July 2016) DOI: /j.str Copyright © 2016 Elsevier Ltd Terms and Conditions

2 Figure 1 A Schematic Depicting the Change in Conformation of the Triphosphate of GTP upon Binding of AG to APH(2″)-Ia In the open conformation, the Gly-loop in teal is located somewhat afar from GTP, whereas upon binding of an AG, this molecular switch flips “on” by lowering itself toward GTP. Structure  , DOI: ( /j.str ) Copyright © 2016 Elsevier Ltd Terms and Conditions

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