1. Supplementary figure 1

2. Supplementary figure 2 Deletion No CNA Amplification MCL1
BCL2
BCL2A1
BCL2L1 (bcl-xl)
BCL2L2 (bcl-w)
MCL1 (57%)
BOK
BIK
BAK1
BAX
BAD
BMF
HRK
BIM (BCL2L11)
Anti-apoptotic BCL2
family members
Pro-apoptotic BCL2
family members
MCL1

3. Supplementary figure 3 A B C

4. Supplementary figure 4

5. Supplementary figure 5

6. Supplementary figure 6 A B

7. Supplementary figure 7 Untreated (4 weeks) S44563 (4 weeks)
Bleomycin (4 weeks)
Bleomycin + S44563 (4 weeks)
Untreated (15 weeks)
S44563 (15 weeks)
IR (15 weeks)
IR + S44563 (15 weeks)

8. Supplementary figure 8
Time (days)
Tumor volume IR
IR*2
Excised tumor