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Supplementary figure 1
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Supplementary figure 2 Deletion No CNA Amplification MCL1
BCL2 BCL2A1 BCL2L1 (bcl-xl) BCL2L2 (bcl-w) MCL1 (57%) BOK BIK BAK1 BAX BAD BMF HRK BIM (BCL2L11) Anti-apoptotic BCL2 family members Pro-apoptotic BCL2 family members MCL1
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Supplementary figure 3 A B C
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Supplementary figure 4
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Supplementary figure 5
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Supplementary figure 6 A B
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Supplementary figure 7 Untreated (4 weeks) S44563 (4 weeks)
Bleomycin (4 weeks) Bleomycin + S44563 (4 weeks) Untreated (15 weeks) S44563 (15 weeks) IR (15 weeks) IR + S44563 (15 weeks)
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Supplementary figure 8 Time (days) Tumor volume IR IR*2 Excised tumor
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