1. Important Elements for the Diagnosis of Drug-Induced Liver Injury
Vijay K. Agarwal, John G. McHutchison, Jay H. Hoofnagle 
Clinical Gastroenterology and Hepatology 
Volume 8, Issue 5, Pages (May 2010)
DOI: /j.cgh
Copyright © 2010 AGA Institute Terms and Conditions

2. Figure 1
Exclusion of a competing viral etiology. Among 97 published case reports of drug-induced liver disease related to specific drugs, fewer than half specified whether competing viral etiologies were excluded. “Viral Screen Negative” represents the percentage of cases for which results of tests for competing etiology were reported vaguely (eg, tests for hepatitis A, B, and C were negative). HAV, hepatitis A virus; HBc, hepatitis B core antibody; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; Ig, immunoglobulin.
Clinical Gastroenterology and Hepatology 2010 8, DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

3. Figure 2
Minimal elements reported in published case reports of hepatotoxicity with thiazolidinediones. Reports were regarding troglitazone (n = 32), rosiglitazone (n = 10), and pioglitazone (n = 8). Rechallenge refers to whether a rechallenge with the same medication was reported as being performed or not. ANA, antinuclear antibody; AP, alkaline phosphatase; HAV, hepatitis A virus; HBc, hepatitis B core antibody; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus.
Clinical Gastroenterology and Hepatology 2010 8, DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

4. Figure 3
Minimal elements reported in published case reports of hepatotoxicity with leukotriene-receptor antagonists. Reports were regarding zafirlukast (n = 8) and montelukast (n = 4). Rechallenge refers to whether a rechallenge with the same medication was reported as being performed or not. ANA, antinuclear antibody; AP, alkaline phosphatase; HAV, hepatitis A virus; HBc, hepatitis B core antibody; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus.
Clinical Gastroenterology and Hepatology 2010 8, DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

5. Figure 4
Minimal elements reported in published case reports of hepatotoxicity with amoxicillin/clavulanic acid (n = 35). Rechallenge refers to whether a rechallenge with the same medication was reported as being performed or not. ANA, antinuclear antibody; AP, alkaline phosphatase; HAV, hepatitis A virus; HBc, hepatitis B core antibody; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus.
Clinical Gastroenterology and Hepatology 2010 8, DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions