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The Case of the Disappearing Drug Target

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Presentation on theme: "The Case of the Disappearing Drug Target"— Presentation transcript:

1 The Case of the Disappearing Drug Target
John T. Prince, Natalie G. Ahn  Molecular Cell  Volume 37, Issue 4, Pages (February 2010) DOI: /j.molcel Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Modulation of In Vivo Drug Kinetics by Protein-Protein Interactions (A) Inhibition of PKC by kinase inhibitor is suppressed by AKAP79, which competes with certain inhibitors for binding to PKC. The evidence points toward direct competition. (B) PKCβII binds PDK1, diminishing the potency of PDK1 inhibitors. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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