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Genetic Analysis of PSORS1 Distinguishes Guttate Psoriasis and Palmoplantar Pustulosis
Kati Asumalahti, Mahreen Ameen, Sari Suomela, Eva Hagforsen, Gerd Michaëlsson, Julie Evans, Margo Munro, Colin Veal, Michael Allen, Joyce Leman, A. David Burden, Brian Kirby, Maureen Connolly, Christopher E.M. Griffiths, Richard C. Trembath, Juha Kere, Ulpu Saarialho-Kere, Jonathan N.W.N. Barker Journal of Investigative Dermatology Volume 120, Issue 4, Pages (April 2003) DOI: /j x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Immunohistochemical staining using HCR antibodies on GP (A) showed strong staining in the basal keratinocytes particularly at the tips of dermal papillae. In PPP samples (C,D) much less HCR expression was detected with only occasional basal keratinocytes bordering dermal papillae at the sides of blisters showing staining. Normal sole skin used as a control (B) was mostly negative with a few positive nuclei in the upper epidermis. Higher magnification showed that in GP (F) mostly the nuclei of keratinocytes were stained and in PPP (G) cytoplasmic staining was more common. (E) Pre-immune serum did not stain any skin structures. Journal of Investigative Dermatology , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions
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