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Coxibs—Beyond the GI Tract

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Presentation on theme: "Coxibs—Beyond the GI Tract"— Presentation transcript:

1 Coxibs—Beyond the GI Tract
Anthony N. DeMaria, MD, Matthew R. Weir, MD  Journal of Pain and Symptom Management  Volume 25, Issue 2, Pages (February 2003) DOI: /S (02)

2 Fig. 1 Distribution of COX-1 and COX-2 in the human kidney.
Journal of Pain and Symptom Management  , 41-49DOI: ( /S (02) )

3 Fig. 2 Role of prostaglandins in the kidney.
Journal of Pain and Symptom Management  , 41-49DOI: ( /S (02) )

4 Fig. 3 Vascular events with rofecoxib: meta-analysis of studies of (6 months' duration or more).41 Relative risk (95% CI) of the APTC (Antiplatelet Trialist Collaboration) end point for rofecoxib relative to placebo, non-naproxen NSAIDs, and naproxen in studies ≥6 months in duration. Triangles represent relative risk, and size of triangles represents patient-years of exposure. Journal of Pain and Symptom Management  , 41-49DOI: ( /S (02) )


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