1. Structural overview.
Structural overview. (A) Domain organization of LRRK2. The residue boundary of the WD40 domain and locations of three recurrent disease mutations are marked. (B) Ribbon diagram using rainbow gradient color from blue at the N terminus to red at the C terminus. The locations of the seven blades are marked. Two views are shown. (C) Electrostatic surface diagram showing a prominent hole in the middle of the structure. (D) Mapping of sequence conservation onto the WD40 domain structure. The view of the bottom surface is at the same orientation as B, Left.
Pengfei Zhang et al. PNAS doi: /pnas
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