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Measuring and improving respiratory outcomes in cystic fibrosis lung disease: Opportunities and challenges to therapy  Edith T. Zemanick, J. Kirk Harris,

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Presentation on theme: "Measuring and improving respiratory outcomes in cystic fibrosis lung disease: Opportunities and challenges to therapy  Edith T. Zemanick, J. Kirk Harris,"— Presentation transcript:

1 Measuring and improving respiratory outcomes in cystic fibrosis lung disease: Opportunities and challenges to therapy  Edith T. Zemanick, J. Kirk Harris, Steven Conway, Michael W. Konstan, Bruce Marshall, Alexandra L. Quittner, George Retsch-Bogart, Lisa Saiman, Frank J. Accurso  Journal of Cystic Fibrosis  Volume 9, Issue 1, Pages 1-16 (January 2010) DOI: /j.jcf Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions

2 Fig. 1 a. Mean Centers for Disease Control (CDC) body mass index (BMI) percentiles versus age with 95% confidence intervals. BMI was higher at each age in 2007 compared to CFF Patient Registry Data [16]. b. Mean forced expiratory volume in 1s (FEV1) percent predicted versus age with 95% confidence intervals. Lung function was higher at each age in 2007 compared to Data from CFF Patient Registry, 1990 and 2007 [16]. Journal of Cystic Fibrosis 2010 9, 1-16DOI: ( /j.jcf ) Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions

3 Fig. 2 Multifactorial causes of variability in outcomes. CFTR = Cystic Fibrosis Transmembrane Conductance Regulator. Adapted from original provided by Michael Schechter, MD, Emory University, Atlanta, GA, USA. Journal of Cystic Fibrosis 2010 9, 1-16DOI: ( /j.jcf ) Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions


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